Disseminated oxacillin-resistant Staphylococcus aureus infection responsive to vancomycin and quinupristin-dalfopristin combination therapy
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منابع مشابه
Quinupristin/dalfopristin: therapeutic potential for vancomycin-resistant enterococcal infections.
Vancomycin-resistant Enterococcus faecium (VREF) is an opportunistic pathogen, which causes infections among severely ill, hospitalized patients, in whom it is likely to increase the risk of progressive local or systemic disease and to worsen the prognosis. Because these organisms are often highly resistant to penicillin, ampicillin and many other antimicrobials including the glycopeptides, the...
متن کاملTreatment of vancomycin-resistant Enterococcus faecium infections with quinupristin/dalfopristin.
Clinicians caring for patients with vancomycin-resistant Enterococcus faecium (VREF) infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin (Synercid) is active in vitro against VREF, with a MIC(90) of 1.0 microg/mL. We investigated the clinical efficacy and safety of this agent in a multicenter, prospective, noncomparative, emergency-use study of 396 patien...
متن کاملSynergy testing of vancomycin-resistant Enterococcus faecium against quinupristin-dalfopristin in combination with other antimicrobial agents.
Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium (VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exh...
متن کاملTreatment of vancomycin-resistant enterococcal infections in the immunocompromised host: quinupristin-dalfopristin in combination with minocycline.
Between February 1994 and November 1998, 56 oncology patients infected with vancomycin-resistant enterococci (VRE) were treated with quinopristin-dalfopristin (Q-D) plus minocycline (MIN). Infections included bacteremia, urinary tract infection, pneumonia, and wound infection. The response rate was 68%, and the most frequent adverse event was arthralgia or myalgia (36%). Q-D-MIN is effective fo...
متن کاملQuinupristin/dalfopristin in Staphylococcus aureus endophthalmitis: a case report
INTRODUCTION The intravitreal injection of antibiotics remains the mainstay of therapy for postoperative endophthalmitis. Bacterial resistance, however, is still a pitfall in achieving an adequate response to treatment. Quinupristin/dalfopristin might be a feasible therapeutic option in these cases. CASE PRESENTATION A 55-year-old Hispanic man had endophthalmitis secondary to Staphylococcus a...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2002
ISSN: 1460-2091
DOI: 10.1093/jac/dkg025